TenSkin™ - mimics in vivo response
What is TenSkin™?
Cultured under an optimal mechanical tension, TenSkin™ provides the user with skin that not only behaves like skin on the body, but which also feels realistic and is therefore more appropriate for evaluating skin treatments, including topical application, micro needle, and intradermal injections. TenSkin™ is suitable for a wide range of applications including wound healing, compound efficacy assessment and response to UV radiation. Follow the links below to find out more about TenSkin™ applications.
Why is TenSkin™ different?
- Ten Bio’s innovative real human skin model advances preclinical testing to new levels by providing the most physiologically relevant system for use in a wide range of applications.
- TenSkin™ maintains skin’s inherent viability and ability to respond to external stimuli through a next-generation culture technology which maintains the tissue under an optimum mechanical tension mimicking the in vivo environment.
- By maintaining skin integrity for 2+ weeks, it is now possible to fully investigate complex skin responses and processes including wound healing and skin rejuvenation.
14 days Viability Immunocompetent Physiological Tension Biologically Relevant TenSkin™
Full thickness human skin
TenSkin™ incorporates normal full-thickness human abdominal skin, including complete dermal and epidermal layers, and features normal barrier function provided by an intact stratum corneum.
The presence of minor skin cell populations, such as immune and pigment cells, together with normal appendages, such as hair follicles and sweat glands, offers researchers a valuable tool to bridge the gap between ex vivo and in vivo studies.
TenSkin™
TenSkin™
TenSkin™
The human skin in TenSkin™ responds like it would in vivo, delivering predictive results contributing to a more efficient development process.
Mechanical tension is an essential factor in biological tissue morphology and function. It influences cell proliferation and differentiation, stimulates extracellular matrix production and tissue remodeling, and allows tissues to adapt and respond to changes in mechanical loading. Skin on the body is under a consistent range of physiological tension. When skin is removed from the body for use in ex vivo assays, this tension is lost, reducing its viability and ability to respond to external stimuli as it would when on the body.
TenSkin™
TenSkin™
TenSkin™
Economical and ethical research
TenSkin™ is prepared from ethically sourced and fully consented surplus surgical tissue and arrives in a ready-to-use format suitable for topical, diffusion and intradermal applications. The skin tissue is harvested, processed and pathogen tested rapidly, the same day as surgery and usually within 8 hours, to ensure the performance of the model is optimised. Fully consented skin is sourced from an established network of surgical clinics ensuring both timely delivery of client requests and access to a wide range of donor age and skin types.
Applications of TenSkin™
Wound healing
Injections
Skin Rejuvenation
Photobiology
Systemic Treatment
Barrier Measurements
Immunnocompetent
Microneedles
Environmental Control
Response to Pollution
Custom Solutions
Disease Models
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