Publications
Discover our scientific publications
Welcome to Ten Bio’s publications hub, where we showcase the latest scientific research and findings from our team and our collaborators. Our commitment to advancing skin biology and ex vivo skin models is reflected in the work we contribute to the field. Here, you’ll find a collection of our peer-reviewed papers, poster presentations, and articles, highlighting our dedication to innovation and collaboration within the scientific community.
A tensioned human skin explant model used for preliminary assessment of chemexfoliant-stimulated bioeffects
Our latest study, using the TenSkinᵀᴹ model, demonstrates how our ex vivo platform is delivering biologically relevant insights into the effects of chemexfoliation (chemical peel) treatments on human skin.
Preliminary assessment of microneedle wound healing in a full-thickness ex vivo human skin model cultured at physiological tension
This study evaluated skin recovery using the TenSkin™ model after microneedle application (dissolvable and non-dissolving types). Histological and immunofluorescence analyses tracked wound healing, comparing results with laser ablation.
The effect of mechanical tension on bolus morphology and integration following intradermal injection in an ex vivo human skin model
Intradermal injection studies benefit from ex vivo human skin models, but traditional relaxed-state models lack physiological tension, impacting tissue integrity and fiber alignment. The TenSkin™ model addresses this, offering more accurate dermal responses and improved integration of hyaluronic acid-based fillers.
Tissue integration of hyaluronic acid -containing dermal fillers: an optimized approach using tensioned ex-vivo human skin
Using the TenSkin™ ex-vivo model, this study highlights the importance of mechanical tension in assessing dermal filler integration. TenSkin™ provides a reliable platform for evaluating filler performance and guiding product development.
Tension as a key factor in skin responses to pollution
This study explores how physiological tension affects skin responses to ozone pollution using the TenSkin™ model. Findings reveal tension modulates the expression of antimicrobial peptides and markers of oxidative stress and inflammation, highlighting its importance in skin health studies.
Mechanical tension influences the immunocompetency of ex vivo skin tissue
Human-relevant testing methods using donated skin tissue offer a promising alternative to animal models. Our ex vivo culture system restores physiological tension in skin, preserving structure, function, and immune cells like Langerhans cells, enabling immune activation studies for up to seven days.
Comparative wound healing in cultured tissues vs ex-vivo tissues
This study compared a 3D cultured skin model with Ten Bio’s tensioned ex vivo TenSkin model for battlefield wound simulation. Results showed TenSkin more closely replicates healing seen in trauma patients, making it a superior platform for injury research.
Exploring UVC light for virus control
Ten Bio is contributing to a collaborative research project led by the University of St Andrews, funded by Innovate UK, to investigate the use of UVC light in inactivating airborne viruses.
Wounding response and wound healing in a novel tension-based skin explant model
This study highlights a tensioned ex vivo skin model that maintains viability and replicates in vivo wound healing. Improved keratin expression and 3D visualization confirm its value for studying biomarkers and testing therapies.