Skin rejuventation
Extended culture periods for evaluation of dermal remodelling
The TenSkin™ culture technology results in skin that mimics in vivo biology and also maintains the surface properties of the skin. TenSkin™ is an ideal platform for evaluation of topical application as the tensioned skin presents identically to a patient’s skin.
Extended culture periods make TenSkin™ ideal for evaluating dermal remodelling (e.g., inhibition of collagen breakdown and stimulation of collagen synthesis). Here, increased procollagen 1 is observed 14 days following topical treatment. TenSkin™ treated with RTA-408 (an NRF2 activator) exhibited a biological response (i.e., upregulation of NQOl mRNA) similar to in vivo data, while traditional ex vivo models (cultured without tension) showed little response.
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Ten Bio works with an established network of surgical clinics to obtain fully consented tissue from a broad range of donor age groups and all Fitzpatrick skin types, providing custom solutions to support even the most complex R&D requirements.